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MOTS-c Peptide – 99%+ Verified Purity

Mitochondrial-derived 16-amino-acid research peptide. Encoded within the 12S rRNA region of mitochondrial DNA. Independently third-party tested. Available in 20mg and 40mg lyophilized vials.

Price range: $109.99 through $179.99

20 mg | 40mg per vial

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Research Compound Profile

What Is MOTS-c Peptide?

MOTS-c (Mitochondrial Open reading frame of the 12S rRNA-c) is a 16-amino-acid research peptide encoded within the mitochondrial genome – specifically within the 12S rRNA region of mitochondrial DNA. Also referenced as MOTS c and occasionally as mot c, MOTS-c has been examined in published research literature as one of a small group of mitochondrial-derived peptides that influence cellular signaling research models.

The MOTS-c research peptide supplied by Genryse is synthesized to a verified 99%+ purity threshold, lyophilized for stability, and supplied strictly for in-vitro laboratory research, analytical work, and controlled scientific study. Genryse MOTS-c is not supplied for human consumption, dietary use, weight management, anti-aging application, or veterinary application.

MOTS-c sits within the Longevity / Cellular / Wellness Research category alongside NAD+, SS-31, Thymosin Alpha 1, GHK-Cu, Cerebrolysin, and Melanotan II.

Research Context

How MOTS-c Peptide Is Discussed in Research

MOTS-c has been examined in preclinical research models. The published research literature documents investigations into the peptide’s potential role in mitochondrial-cellular signaling, AMPK pathway research, and cellular-metabolism research. None of the descriptions below describe human use, treatment outcomes, weight-loss claims, anti-aging claims, or clinical recommendations – they summarize how the MOTS-c research peptide has been characterized in published in-vitro and animal-model studies.

Research investigators have examined MOTS-c Peptide in the context of:

Mitochondrial-derived peptide research in controlled in-vitro systems
AMPK pathway research in cell-based assays
Mitochondrial signaling research in animal models
Cellular-metabolism research in defined laboratory conditions
Comparative mitochondrial peptide research vs SS-31 and other mitochondrial compounds

All findings discussed in the published research literature are derived from in-vitro and in-vivo animal-model studies and are exploratory in nature. Genryse supplies MOTS-c Peptide as a research peptide for these laboratory-research purposes only.

Technical Data

MOTS-c Peptide Product Specifications

Product name	MOTS-c Peptide (also referenced as MOTS c, mot c, mitochondrial-derived peptide)
Sequence	16-amino-acid mitochondrial-derived peptide; encoded within 12S rRNA mtDNA region
CAS number	1627580-64-6
Form supplied	Lyophilized powder, vialed
Sizes available	20mg \| 40mg
Verified purity	99%+ (HPLC)
Identity verification	Mass spectrometry
COA	Available for every lot
Country of origin	USA
Intended use	In-vitro laboratory research only

Quality Assurance

Purity, COA, and Third-Party Testing

Every Genryse MOTS-c Peptide research peptide is independently verified by third-party laboratories. Each batch undergoes HPLC testing for 99%+ purity and mass-spectrometry verification for molecular identity. A Certificate of Analysis is generated for every lot of MOTS-c Peptide we supply, and is available for review on the COA library page.

Genryse does not ship a research peptide without a COA. This is a non-negotiable element of how we supply MOTS-c Peptide to qualified research professionals.

📄 Download Sample MOTS-c Peptide COA (PDF) →

View Lab Testing Methodology Download Sample COA

Storage Protocols

MOTS-c Peptide Storage and Handling

Lyophilized MOTS-c Peptide should be stored at -20°C, protected from light, until reconstitution. Once reconstituted, MOTS-c Peptide should be stored at 2–8°C and used within the timeframe specified on the lot’s COA. Maintain aseptic handling practices to preserve research peptide integrity.

For comprehensive handling and reconstitution practices, refer to the Genryse peptide storage guide.

📘 View Peptide Storage Guide →

Longevity & Cellular Research Cluster

Related Research Peptides

Researchers studying MOTS-c Peptide frequently work alongside the following research peptides supplied by Genryse:

Browse Longevity / Cellular / Wellness Research →

Published Literature

Research References

Selected published research literature referencing MOTS-c Peptide:

Lee C et al., Cell Metab, 2015;21(3):443–454
Kim KH et al., Cell Metab, 2018;28(3):516–524
Reynolds JC et al., Nat Commun, 2021;12(1):470
Lu H et al., Aging Cell, 2019;18(1):e12892

All references are provided for research-context purposes only. Genryse does not endorse, replicate, or imply outcomes from these studies.

Research Peptide Calculator Research Use Disclaimer View All COA Results

MOTS-c Peptide – Frequently Asked Questions

What is MOTS-c peptide?

MOTS-c (Mitochondrial Open reading frame of the 12S rRNA-c) is a 16-amino-acid research peptide encoded within the mitochondrial genome. Also referenced as MOTS c and mot c, MOTS-c has been examined in research literature as one of a small group of mitochondrial-derived peptides. Genryse supplies MOTS-c as a research peptide for in-vitro laboratory research only.

How is MOTS-c different from SS-31 in mitochondrial research?

MOTS-c is an endogenous mitochondrial-derived research peptide encoded within mitochondrial DNA – examined in research as a signaling peptide originating from the mitochondria itself. SS-31 is a synthetic mitochondrial-targeted research peptide examined in research models of mitochondrial function. They represent different research approaches: MOTS-c as an endogenous mitochondrial-derived peptide research model, SS-31 as a synthetic mitochondria-localized research peptide.

What sizes of MOTS-c does Genryse offer?

Genryse MOTS-c is supplied in two lyophilized vial sizes: 20mg and 40mg. Each size ships with 99%+ purity verification and a lot-specific COA.

What is MOTS-c examined for in research?

MOTS-c has been examined in preclinical research models for its potential role in mitochondrial-cellular signaling, AMPK pathway research, and cellular-metabolism research. Genryse supplies MOTS-c as a research compound for in-vitro laboratory research only – not for human consumption, weight loss, or anti-aging application.

How should MOTS-c research peptide be stored?

Lyophilized MOTS-c should be stored at -20°C until reconstitution, then at 2–8°C following reconstitution. Maintain aseptic handling practices and refer to the lot-specific COA and the Genryse peptide storage guide for full handling protocols.

Is MOTS-c supplied for weight loss or anti-aging?

No. MOTS-c supplied by Genryse is a research peptide intended exclusively for in-vitro laboratory research and analytical study. It is not intended for weight loss, weight management, anti-aging application, longevity supplementation, human consumption, dietary supplementation, athletic application, veterinary application, or any clinical use.

Does MOTS-c ship with a COA?

Yes. Every Genryse MOTS-c research peptide ships with a lot-specific Certificate of Analysis verifying 99%+ purity and molecular identity. Sample COAs are available for review prior to purchase.

Warning — For Research Use Only

FDA Disclaimer: The statements made within this website have not been evaluated by the U.S. Food and Drug Administration. The research peptides supplied by Genryse are not intended to diagnose, treat, cure, or prevent any disease.

For Research Purposes Only

Not a Dietary Supplement

Not for Human Consumption

Not for Veterinary Use